Reduce Cholesterol Levels Diet

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The two researchers from the University of Texas Southwestern Medical Center went on to show that the subjects were protected from heart disease. Reduce Cholesterol Levels Diet the findings strongly suggested the possible benefits of blocking PCSK9 or its activity. Two young women found to have no PCSK9 at all had LDL levels of just 14 to 16 — one-eighth normal levels.

Data from a similar HDL-raising drug being developed by Roche Holding AG will be released on Sunday at the annual meeting of the European Society of Cardiology in Paris. But cutting LDL cholesterol remains the most proven way of reducing heart attacks and stroke and is the industry’s prime focus. Should PCSK9 inhibitors stumble it would be a keen disappointment for some of the world’s biggest drugmakers.

Some drugs might eventually be administered every two to three months he said. Amgen Inc Merck & Co Alnylam Pharmaceuticals Inc and a partnership between Bristol-Myers Squibb Co and Isis Pharmaceuticals Inc are in hot pursuit with rival drugs of their own. The anti-PCSK9 medicines are expected to be used alongside statins such as Pfizer’s Lipitor and Astra Zeneca Plc’s Crestor for Reduce Cholesterol Levels Diet patients who do not achieve cholesterol-lowering goals with statins alone. They would also be used on their own for a much smaller group who cannot tolerate statins — oral drugs with global annual sales Reduce Cholesterol Levels Diet of $20 billion that inhibit the liver’s production of LDL cholesterol. In the United States more than 10 million patients could ultimately be candidates for the new family of medicines. Industry analysts say the products could command $1000 a month or more because of their potential importance to high-risk patients. Statins cost about $130 a month for branded pills like Lipitor which is due to lose U.

The two researchers from the University of Texas Southwestern Medical Center went on to show that the subjects were protected from heart disease. The findings strongly suggested the possible benefits of blocking PCSK9 or its activity. Two young women found to have no PCSK9 at all had LDL levels of just 14 to 16 — one-eighth normal levels.

The anti-PCSK9 medicines are expected to be used alongside statins such as Pfizer’s Lipitor and Astra Zeneca Plc’s Crestor for patients who do not achieve cholesterol-lowering goals with statins alone. They would also be used on their own for a much smaller group who cannot tolerate statins — oral drugs with global annual sales of $20 billion that inhibit the liver’s production of LDL cholesterol. In the United States more than 10 million patients could ultimately be candidates for the new family of medicines.

While early studies focused on patients with genetic mutations that triggered sky-high production of LDL Helen Hobbs and colleague Jonathan Cohen theorized in 2005 that other mutations in PCSK9 might exist and have the opposite effect: of inactivating the gene and thereby leading to lower LDL levels. They examined the structure of the gene in African-Americans who had low LDL. Their research showed that 2 percent of them had an inherited mutated form of the gene and that their LDL levels were about a third lower than individuals without the mutation.

Inustry analysts say the products could command $1000 a month or more because of their potential importance to high-risk patients. Statins cost about $130 a month for branded pills like Lipitor which is due to lose U. S.

Insight: Next big drug against cholesterol takes shape They work by blocking PCSK9 a protein whose natural function is to preserve levels of “bad” LDL cholesterol in the bloodstream. Researchers in Paris Montreal and Dallas through experiments with thousands of patients that began in 1999 discovered the gene behind PCSK9 and deciphered its function. Biotechnology company Regeneron and its big pharmaceutical partner Sanofi are now ahead of the pack in developing a drug that goes after PCSK9.

Steinberg who has written extensively on PCSK9 said that patients with the protective mutation were shown to have an almost 90 percent reduced risk of coronary artery disease compared with the general population. Steinberg said anti-PCSK9 drugs could save

Reduce Cholesterol Levels Diet

tens of thousands of lives a year as statins now do. Statins actually raise levels of PCSK9 thereby undermining their own effectiveness in reducing LDL. Patients taking PCSK9 inhibitors might also be able to take Reduce Cholesterol Levels Diet lower doses of statins and thereby avoid their side effects such as muscle weakness and liver toxicity. Some studies suggest PCSK9 may help regenerate liver tissue so drugs that block it theoretically could pose a risk to alcoholics or others with existing liver damage. Studies will test the liver risk and also show whether the new medicines affect HDL cholesterol or cause side effects in other organswhere PCSK9 is concentrated.

Industry analysts say the products could command $1000 a month or more because of their potential importance to high-risk patients. Statins cost about $130 a month for branded pills like Lipitor which is due to lose U. S. patent protection later this year or far less for other products already available as generics. Data from initial studies suggests REGN727 may be able to reduce LDL by another 50 percent when used in combination with statins which themselves can cut LDL in half. His firm is one of Regeneron’s largest shareholders with a 9.

She cited torcetrapib a drug to raise “good” HDL cholesterol that Pfizer had expected to reap annual sales of more than $10 billion. Meant to drive down the incidence of heart attacks the drug instead was linked to deaths and was scrapped in 2006 after costly late-stage trials. Data from a similar HDL-raising drug being developed by Roche Holding AG will be released on Sunday at the annual meeting of the European Society of Cardiology in Paris. But cutting LDL cholesterol remains the most proven way of reducing heart attacks and stroke and is the industry’s prime focus.

Studies will test the liver risk and also show whether the new medicines affect HDL cholesterol or cause side effects in other organs where PCSK9 is concentrated. While safety must be established Alnylam research executive Akshay Vaishnaw is betting on PCSK9 drugs. It’s absolutely going to be the next big thing.

Data from initial studies suggests REGN727 may be able to reduce LDL by another 50 percent when used in combiation with statins which themselves can cut LDL in half. His firm is one of Regeneron’s largest shareholders with a 9.5 percent stake as of the end of June. Assuming longer-term studies demonstrate the drug is safe and prevents heart attacks and stroke Bakri estimates it could capture annual sales “in the billions of dollars” if approved. But she cautioned that other classes of novel medicines have stumbled because of Reduce Cholesterol Levels Diet unexpected safety problems.

They examined the structure of the gene in African-Americans who had low LDL. Their research showed that 2 percent of them had an inherited mutated form of the gene and that their LDL levels were about a third lower than individuals without the mutation. The two researchers from the University of Texas Southwestern Medical Center went on to show that the subjects were protected from heart disease. The findings strongly suggested the possible benefits of blocking PCSK9 or its activity. Two young women found to have no PCSK9 at all had LDL levels of just 14 to 16 — one-eighth normal levels. Yet they were deemed to be in good health suggesting to Hobbs and others that blocking PCSK9 may not pose great safety risks.

Data from a similar HDL-raising drug being developed by Roche Holding AG will be released on Sunday at the annual meeting of the European Society of Cardiology in Paris. But cutting LDL cholesterol remains the most proven way of reducing heart attacks and stroke and is the industry’s prime focus. Should PCSK9 inhibitors stumble it would be a keen disappointment for some of the world’s biggest drugmakers.

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